Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms

TitleGenome-wide association meta-analysis of childhood and adolescent internalizing symptoms
Publication TypeJournal Article
Year of Publication2022
AuthorsJami, ES, Hammerschlag, AR, Ip, HF, Allegrini, AG, Benyamin, B, Border, R, Diemer, EW, Jiang, C, Karhunen, V, Lu, Y, Lu, Q, Mallard, TT, Mishra, PP, Nolte, IM, Palviainen, T, Peterson, RE, Sallis, HM, Shabalin, AA, Tate, AE, Thiering, E, Vilor-Tejedor, N, Wang, C, Zhou, A, Adkins, DE, Alemany, S, Ask, H, Chen, Q, Corley, RP, Ehli, EA, Evans, LM, Havdahl, A, Hagenbeek, FA, Hakulinen, C, Henders, AK, Hottenga, JJan, Korhonen, T, Mamun, A, Marrington, S, Neumann, A, Rimfeld, K, Rivadeneira, F, Silberg, JL, van Beijsterveldt, CE, Vuoksimaa, E, Whipp, AM, Tong, X, Andreassen, OA, Boomsma, DI, Brown, SA, S Burt, A, Copeland, W, Dick, DM, K Harden, P, Harris, KMullan, Hartman, CA, Heinrich, J, Hewitt, JK, Hopfer, C, Hypponen, E, Jarvelin, M-R, Kaprio, J, Keltikangas-Järvinen, L, Klump, KL, Krauter, K, Kuja-Halkola, R, Larsson, H, Lehtimäki, T, Lichtenstein, P, Lundström, S, Maes, HH, Magnus, P, Munafò, MR, Najman, JM, Njølstad, P\aalR, Oldehinkel, AJ, Pennell, CE, Plomin, R, Reichborn-Kjennerud, T, Reynolds, C, Rose, RJ, Smolen, A, Snieder, H, Stallings, M, Standl, M, Sunyer, J, Tiemeier, H, Wadsworth, SJ, Wall, TL, Whitehouse, AJO, Williams, GM, Ystrøm, E, Nivard, MG, Bartels, M, Middeldorp, CM
JournalJournal of the American Academy of Child & Adolescent Psychiatry
Keywordsanxiety, depression, genetic epidemiology, molecular genetics, repeated measures

OBJECTIVE: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence.

METHOD: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument.

RESULTS: The meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48