Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people

TitleGenome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people
Publication TypeJournal Article
Year of Publication2022
AuthorsEising, E, Mirza-Schreiber, N, de Zeeuw, EL, Wang, CA, Truong, DT, Allegrini, AG, Shapland, CYang, Zhu, G, Wigg, KG, Gerritse, ML, Molz, B, Alagöz, G, Gialluisi, A, Abbondanza, F, Rimfeld, K, van Donkelaar, M, Liao, Z, Jansen, PR, Andlauer, TFM, Bates, TC, Bernard, M, Blokland, K, Bonte, M, Børglum, AD, Bourgeron, T, Brandeis, D, Ceroni, F, Csépe, V, Dale, PS, de Jong, PF, DeFries, JC, Démonet, J-F\ccois, Demontis, D, Feng, Y, Gordon, SD, Guger, SL, Hayiou-Thomas, ME, Hernández-Cabrera, JA, Hottenga, J-J, Hulme, C, Kere, J, Kerr, EN, Koomar, T, Landerl, K, Leonard, GT, Lovett, MW, Lyytinen, H, Martin, NG, Martinelli, A, Maurer, U, Michaelson, JJ, Moll, K, Monaco, AP, Morgan, AT, Nöthen, MM, Pausova, Z, Pennell, CE, Pennington, BF, Price, KM, Rajagopal, VM, Ramus, F, Richer, L, Simpson, NH, Smith, SD, Snowling, MJ, Stein, J, Strug, LJ, Talcott, JB, Tiemeier, H, van der Schroeff, MP, Verhoef, E, Watkins, KE, Wilkinson, M, Wright, MJ, Barr, CL, Boomsma, DI, Carreiras, M, Franken, M-CJ, Gruen, JR, Luciano, M, Müller-Myhsok, B, Newbury, DF, Olson, RK, Paracchini, S, Paus, T\vs, Plomin, R, Reilly, S, Schulte-Körne, G, J Tomblin, B, van Bergen, E, Whitehouse, AJO, Willcutt, EG, St Pourcain, B, Francks, C, Fisher, SE
JournalProceedings of the National Academy of Sciences U. S. A.
Volume119
Paginatione2202764119
Keywordsgenome-wide association study, language, Meta-analysis, reading
Abstract

The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on the trait. The genetic architecture is complex, heterogeneous, and multifactorial, but investigations of contributions of single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures (word reading, nonword reading, spelling, phoneme awareness, and nonword repetition) in samples of 13,633 to 33,959 participants aged 5 to 26 y. We identified genome-wide significant association with word reading (rs1120800

DOI10.1073/pnas.2202764119