@article {282, title = {Psychotic-like experiences in pre-adolescence: what precedes the antecedent symptoms of severe mental illness?}, journal = {Acta Psychiatrica Scandinavica}, volume = {138}, year = {2018}, pages = {15-25}, abstract = {

OBJECTIVE:

Adolescent psychotic-like experiences predict the onset of psychosis, but also predict subsequent non-psychotic disorders. Therefore, it is crucial to better understand the aetiology of psychotic-like experiences. This study examined whether (a) child emotional and behavioural problems at 3 and 6 years, or (b) childhood adversities were associated with psychotic-like experiences at age 10 years.

METHOD:

This prospective study was embedded in the Generation R Study; 3984 children (mean age 10 years) completed a psychotic-like experiences questionnaire. Mothers reported problems of their child at ages 3, 6 and 10 years. Additionally, mothers were interviewed about their child\&$\#$39;s adversities.

RESULTS:

Psychotic-like experiences were endorsed by ~20\% of children and predicted by both emotional and behavioural problems at 3 years (e.g. emotional-reactive problems: ORadjusted = 1.10, 95\% CI: 1.06-1.15, aggressive behaviour: ORadjusted = 1.03, 95\% CI: 1.02-1.05) and 6 years (e.g. anxious/depressed problems: ORadjusted = 1.11, 95\% CI: 1.06-1.15, aggressive behaviour: ORadjusted = 1.04, 95\% CI: 1.04-1.05). Childhood adversities were associated with psychotic-like experiences (\>2 adversities: ORadjusted = 2.24, 95\% CI: 1.72-2.92), which remained significant after adjustment for comorbid psychiatric problems.

CONCLUSION:

This study demonstrated associations between early adversities, childhood emotional and behavioural problems and pre-adolescent psychotic-like experiences, which will improve the understanding of children at increased risk of severe mental illness.

}, keywords = {childhood adversities, development, prospective, Psychosis, psychotic symptoms}, doi = {10.1111/acps.12891}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.12891}, author = {Koen Bolhuis and Koopman-Verhoeff, M. E. and Blanken, L. M. E. and Cibrev, D. and Vincent W.V. Jaddoe and Frank Verhulst and Manon H.J. Hillegers and Steven A. Kushner and Henning Tiemeier} }